Annual Report 2016 - Mechanical Engineering

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90 Bioseparation Engineering
Bioseparation Engineering
Process development and intensification, particle technology, adsorption, filtration, and extraction
Prof. Dr.
Sonja Berensmeier
New Stationary Phases
New stationary phases are essential in
bioseparation sciences; classical phases
are already well developed and reach
their limits. The Bioseparation Engineering
Group is specialized in synthesis and
functionalization of magnetic particles
and conductive materials as well as their
process implementation. Making use of
magnetism or conductivity allows for an
additional degree of freedom for state-of-
the-art process development.
Projects
n AiF/IFG Project – Synthesis, characteri-
zation and application of new stationary
phases for potential-controlled chroma-
tography
n The Bioseparation Engineering Group deals with different aspects of
the isolation and purification of biomolecules for the pharmaceutical or
chemical industry. We are focused on adsorption, filtration and extraction
as separation methods as well as their integration into the production
process. In addition to the experimental approaches we use COMSOL
and COSMO-RS for modelling and simulation.
selektive-trenntechnik
Phone +49.89.289.15750
Contact
As member of the scientific committee
Prof. Berensmeier provided two scien-
tific conferences in 2016. In March the
1st Industrial Biotechnology Forum (IBF)
was located at the Technical University
of Munich. In autumn the International
Symposium on the Separation of Proteins,
Peptides and Polynucleotides (ISPPP)
Immobilized enzymes on magnetic nanoparticles for
cellulose hydrolysis. Source: Dipl.-Ing. Christian Roth
took place in Salzburg, Austria. For 2018
Prof. Berensmeier will act as conference
chair of the ISPPP.
As from October 2016 we welcome
Priyanka Padwal, Ph.D. from the Indian
Institute of Technology Bombay (ITB) as
a TUM University Foundation Fellow.
Functional Interfaces
In separation sciences the interaction of
particulate carriers among each other and
to target molecules is essential for process
development. Selective interactions as
well as high binding capacities of target
molecules to solid phases determine the
final purity and yield and therefore the
quality in whole of the separation step.
In contrast, uncontrolled aggregation of
particles decreases process performance
concerning robustness, reproducibility,
and scalability. All these aspects are main
focus topics of our projects.
Projects
n BMBF Biotechnology 2020+ initiative
– rational design of peptide-surface
interactions
n Development of new stationary phases
for antibody purification
Structure of Paxclitacel (drug to
treat cancer)
Source: Ljubomir Grozdev, .