116 / 308
116
Bioseparation Engineering
Process Development
In addition to the optimization of classical downstream
processes new innovative separation techniques as
well as integrated process concepts are subjects under
research. A focus area is the research on high-gradient
magnetic separation, potential controlled chromatography,
and membrane assisted extraction.
Projects
■■
BMBF Project – HOBBIT – Development of a sustain-
able separation process for purifying small protective
solutes
■■
BMBF e:Bio initiative – SysBioTerp – innovative strate-
gies for a sustainable production of bioactive molecules
■■
BMBF Project – S3kapel – Multiscale simulation for
electrochemical separation processes
Hydrodynamics in a packed
bed chromatography
Source: Lukas Gerstweiler
Functional Interfaces
In separation sciences the interaction of particulate carri-
ers among each other and to target molecules is essential
for process development. Selective interactions as
well as high binding capacities of target molecules to solid
phases determine the final purity and yield and therefore
the quality in the whole of the separation step.
In contrast, uncontrolled aggregation of particles
decreases process performance with regard to robust-
ness, reproducibility, and scalability. All these aspects are
main focus topics of our projects.
Projects
■■
BMBF Biotechnology 2020+ initiative – rational design
of peptide-surface interactions
■■
Design of new affinity tags for the purification of
recombinant proteins
■■
Development of new stationary phases for antibody
purification
Structure of Paxclitacel
(drug to treat cancer)
Source: Ljubomir Grozdev, M.Sc.