177 / 308
177
Systems Biotechnology
Metabolic Engineering of
Escherichia coli
:
Combing Synthetic and Systems Biology
Escherichia coli
is the organism of choice for basic
research in biotechnology due to the possibility for genetic
alterations as well as its simple culture conditions. In two
projects together with experimental partners from different
places in Munich and Germany,
E. coli
is used for the
production of chemical bulk components or interesting
precursors for medical applications. Based on genome
scale mathematical models, optimal flux distributions and
optimal intervention strategies are determined that make
the processes more efficient.
Project
■■
DynOpt – dynamic process optimization in biotechnol-
ogy, BMBF, biotechnology 2020+ initiative; SysBioTerp
– innovative strategies for a sustainable production of
bioactive molecules, BMBF, e:Bio initiative