Jahresbericht 2017

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Systems Biotechnology
Prof. Dr.-Ing.
Andreas
Kremling
Contact
fg-systembiotechnologie
Phone +49.89.289.15761
Management
Prof. Dr.-Ing. Andreas Kremling, Director
Administrative Staff
Susanne Kuchenbaur
Research Scientists
Dr. Alberto Marin Sanguino
Dr. Katharina Pflüger-Grau
Sabine Wagner, M.Sc.
Hannes Löwe, M.Sc
Miguel Valderrama, M.Sc
Sayuri Hortsch, M.Sc
Kreitmayer, Diana, M.Sc.
Technical Staff
Stefan Darchinger
Research Focus
■■Mathematical modeling of cellular
systems
■■Model analysis
■■Model-based metabolic engineering
■■Experimental design
Competence
■■Model library for different model
systems (metabolic modules, gene
expression modules, signaling
modules)
■■Design space analysis
■■Time hierarchy analysis
■■Process design
Infrastructure
■■S1-Laboratory (allows work with
genetically modified strains)
■■Photo bio-reactor system
■■Standard bio-reactor system
■■Tecan reader
Courses
(for Master ‘Industrial Biotechnology’,
MSE)
■■Applied Mathematics
■■Modeling of Cellular Systems
■■Analysis and Design of Cellular
Systems
■■Optimization in Biotechnology
■■Data Analysis and Statistical Models
■■Exercises in Simulation Studies in
Biotechnology
Publications 2016-17
■■Hahl, S. and Kremling, A.: A compa­
rison of deterministic and stochastic
modelling approaches for biochemical
reaction systems: on fixed points,
means, and modes. Frontiers in
Genetics (7), 157 ff (2016)
■■Löwe, H, Kremling, A., and Marin-
Sanguino, A.: Time hierarchies and
model reduction in canonical non-linear
models. Frontiers in Genetics (7), 166 ff
(2016)
■■Valderrama-Gomez, M.A., Kreitmayer,
D., Wolf, S. Marin-Sanguino, A. and
Kremling, A.: Application of theore­
tical methods to increase succinate
production in engineered strains.
Bioprocess and Biosystems Engin­
eering 40 (4), 479 ff (2017)
■■Löwe, H., Schmauder, L., Hobmeier,
K., Kremling, A. and Pflüger-Grau, K.:
Metabolic engineering to expand the
substrate spectrum of Pseudomonas
putida toward sucrose. Microbiology­
Open, e00473 (2017)
■■Löwe, H., Hobmeier, K., Moos, M.,
Kremling, A., and Pflüger-Grau, K.:
Photoautotrophic production of poly­
hydroxyalkanoates in a synthetic mixed
culture of Synechococcus elongatus
cscB and Pseudomonas putida cscAB.
Biotechnology for Biofuels 10:190
(2017)
■■Kindzierski, V., Raschke, S., Knabe, N.,
Siedler, F., Scheffer, B., Pflüger-Grau, K.
et al.: Osmoregulation in the Halophilic
Bacterium Halomonas elongata: A Case
Study for Integrative Systems Biology.
PLoS ONE12(1): e0168818 (2017)